|Rating||4.64 / 5 ( 2986 votes )|
|Update||(8 days ago)|
The new fantasy action RPG. Rise, Tarnished, and be guided by grace to brandish the power of the Elden Ring and become an Elden Lord in the Lands Between. • A Vast World Full of Excitement A vast world where open fields with a variety of situations and huge dungeons with complex and three-dimensional designs are seamlessly connected. As you explore, the joy of discovering unknown and overwhelming threats await you, leading to a high sense of accomplishment. • Create your Own Character In addition to customizing the appearance of your character, you can freely combine the weapons, armor, and magic that you equip. You can develop your character according to your play style, such as increasing your muscle strength to become a strong warrior, or mastering magic. • An Epic Drama Born from a Myth A multilayered story told in fragments. An epic drama in which the various thoughts of the characters intersect in the Lands Between. • Unique Online Play that Loosely Connects You to Others In addition to multiplayer, where you can directly connect with other players and travel together, the game supports a unique asynchronous online element that allows you to feel the presence of others. ABOUT ELDEN RING GAME: The new fantasy action RPG. Rise, Tarnished, and be guided by grace to brandish the power of the Elden Ring and become an Elden Lord in the Lands Between. • A Vast World Full of Excitement A vast world where open fields with a variety of situations and huge dungeons with complex and three-dimensional designs are seamlessly connected. As you explore, the joy of discovering unknown and overwhelming threats await you, leading to a high sense of accomplishment. • Create your Own Character In addition to customizing the appearance of your character, you can freely combine the weapons, armor, and magic that you equip. You can develop your character according to your play style, such as increasing your muscle strength to become a strong warrior, or mastering magic. • An Epic Drama Born from a Myth A multilayered story told in fragments. An epic drama in which the various thoughts of the characters intersect in the Lands Between. • Unique Online Play that Loosely Connects You to Others In addition to multiplayer, where you can directly connect with other players and travel together, the game supports a unique asynchronous online element that allows you to feel the presence of others.
- A Unique Combat System Called ‘Ring Flow’ that Keeps You on Your A-Game A fantasy world where three kinds of attacks are possible in each attack. They’re easy-to-use and effective, but other characters have a set of attacks with which they weren’t involved, making the fight entertaining. The combat scenes play out in a real-time mode. Enemies continually come at you from various directions and the timing of your attacks takes effect. You enter the Blood of the Gods phase while striking the opponent with a powerful blow. The battle stage becomes fluid and exciting, with your attacks coming along. Go beyond 99% and let your Blood of the Gods fly in these thrilling combat scenes.
- An Every-Day Well-Balanced Game System An ageless system that doesn’t break when you play the game. The balance of this game has been meticulously maintained from the beginning of this game for over ten years and is built on. Even if you play the game for a total of thirty hours, you’ll be able to continue enjoying great battles.
- Lighting and 3D Text that Harness Complete Both Quality and Realism
A simple graphics style with no script processing like an anime.
The lighting takes on a 3D effect as it is affected by the
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Review by Gamerunk on the 11/08/2012 | PLAYED THE GAME “The story is well done. The artwork is very nicely done. The music sounds great. The soundtrack is very excellent. The fight system is simple yet very effective. It’s easy to get into and learn, but also provides a challenge once you get the hang of it. All in all, an amazing game.” Review by Riotboots on the 01/07/2013 | The Story: “The “Magical Journey” of the protagonist and his friends in an open world environment with no specific storyline.” Review by uffidius on the 01/22/2013 | “The story isn’t really there for the game, in a vain effort to force gamers to buy the dlc, nor is it really necessary. All in all though if you enjoy anime, light hearted JRPG and are a fan of the deus ex engine then this is a game that you should play. It’s got lots of charm, a simple combat system, a growing cast of characters who all have different outlooks on the events happening around them and a decent soundtrack to go along with it.” Review by Paladin on the 09/04/2013 | “Short and sweet. Once you go through the tutorial and get into the game itself, the story isn’t really there for the game, in a vain effort to force gamers to buy the dlc, nor is it really necessary. All in all though if you enjoy anime, light hearted JRPG and are a fan of the deus ex engine then this is a game that you should play. It’s got lots of charm, a simple combat system, a growing cast of characters who all have different outlooks on the events happening around them and a decent soundtrack to go along with it.” Review by Psyko on the 01/31/2014 | “Decent storyline, good combat system, and good character development. You get to choose four different protagonists out of eight, each with their own past and their own story to tell.” Review by MrThan86 on the 03/01/2014 | “Let’s just say Elden Ring has a good story and a fun combat system.� bff6bb2d33
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The developer is excited to announce that the new fantasy action RPG, ELDEN RING, will be released at a price of $49.99 on August 20, 2017 in North America on STEAM for PC. The PlayStation®4 version of the game is currently scheduled to launch in December 2017. The game is currently in development and is currently in the last stage of testing prior to its release. Please be patient as this game is developed using Rust as the game engine. If you want to know more details about ELDEN RING, please follow this link. GAME FEATURES 1. A Vast World Full of Excitement In ELDEN RING, the world is mapped out in a 3D space as seen from a top down perspective. The world is comprised of 8 world map areas, each of which are full of unique dungeons, and other areas where you can purchase equipment or take on quests. The 8 world map areas are: -The Great Tree – Which is a tree that has been floating over the world. It contains the paradise city of Luna. -Eden – This is the world of mankind. The city of Eden was founded by seven legendary men named Gyr, Nicol, Largia, Lathia, Ricza, Grotzen and Lumina. In which Largia was the protagonist of the game. -Eden between Rivers – A world of narrow rivers. This is where Campi meets Boss at the North River. It is a world where young Tarnished seek revenge on the Elden Lords. -Northern Almiria- It is a world of multiple small islands. Where the Tarnished live. -The Great Canyon – A world of caves and mountain ridges. In which the people lived at the underground level. A mysterious city was founded there. It was the source of the creation of the Maybell and the creation of the Elden Crystal. -The Peak of the World – A world of large, pinnacles filled with caves and mountains. In which the Elden Lords live. -Pirate Isle – A world of small islands. At the bottom of the great ocean of Piralea. In which the pirates live. -Piralea – A world of large ocean full of sunken ruins. In which the pirates of Piralea live. Luna – A world where the youth
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Assessment of Rho-kinase inhibition in a rat model of myocardial ischaemia/reperfusion injury. Inhibition of Rho-kinase has been reported to be cardioprotective in pre-clinical models of cardiac ischaemia and reperfusion. The aim of this study was to evaluate the potential for Rho-kinase inhibition to attenuate myocardial infarction after ischaemia/reperfusion. Rats were subjected to ischaemia for 45 min and then reperfused for 3 h. Myocardial infarction was determined by 2,3,5-triphenyltetrazolium chloride staining and expressed as a percentage of the total area. Rho-kinase inhibition was achieved by transgenic overexpression of the dominant negative mutant form of Rho-kinase (DN-ROCK) in rats or by continuous intravenous infusion of Y-27632, a specific inhibitor of ROCK. In comparison to wild-type (WT) rats, DN-ROCK overexpressing rats had a 65% reduction in infarct size (P = 0.02). Similarly, rats pretreated with Y-27632 had a 32% reduction in infarct size (P = 0.02). Interestingly, Y-27632 also reduced infarct size in WT rats (31%, P = 0.02), presumably by reducing baseline ROCK expression in WT rats and activating compensatory endogenous pathways. The cardioprotective effect of Y-27632 was maximal in the early phase of reperfusion (Tyrosine phosphorylation of phosducin is involved in the inhibition of G-protein signaling by phosducin. G-proteins are a family of heterotrimeric transmembrane receptors that regulate cellular proliferation, differentiation and survival. They are composed of three subunits, namely, the alpha-subunit, which is coupled to the receptor, and the beta- and gamma-subunits, which bind to guanine nucleotides. The gamma-subunit, in turn, is bound by phosducin, an acidic (pI 5.5) and highly phosphorylated (up to 10% of the total) neuronal protein, which serves as a negative regulator of G
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