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AppsMac is a popular website that distributes high quality apps. We have over 2,000,000 mobile apps in our database and cater to all the latest releases of iOS, Android, Win Phone and BlackBerry.Inhibition of calmodulin by cystine and cystamine.
Cystine and cystamine inhibit calmodulin activity, the extent of inhibition being much higher with cystine than with cystamine. The cystine inhibition of calmodulin activity can be reversed by dithiothreitol, but is unaffected by reducing agents at concentrations effective in reversing the inhibition of calmodulin-dependent enzymes by cystine and cystamine. This suggests that the cystine inhibition of calmodulin is due to the formation of a disulfide bond between cystine and the sulfhydryl group of a cysteine residue in the calmodulin molecule.Obsessive-compulsive disorder (OCD) is a chronic disorder with severe functional impairments. It is characterized by recurrent unwanted, intrusive, and distressing thoughts (obsessions) or repetitive, ritualistic behaviors (compulsions). Although the somatic symptoms associated with OCD are treatable, current treatments for this disorder are typically only effective for about half of patients. New medications and novel treatment approaches for OCD are urgently needed. In a recent study, we found that the molecule ibudilast (a non-specific phosphodiesterase inhibitor that also activates non-peptidergic nociceptive fibers) is an effective treatment for patients with OCD with prominent somatic symptoms. The goals of the current proposal are to investigate (1) the molecular mechanisms of ibudilast’s therapeutic actions, (2) the mechanisms of the psychosocial treatment response of OCD, and (3) the feasibility of translating ibudilast into a potential clinical treatment. We
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